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Regulation of cell proliferation and migration by phosphatidic acid and ceramide 1-phosphate. Implication in lung cancer and inflammation
(2023-12-18)
According to the World Health Organization (WHO), chronic inflammatory lung diseases, includingasthma, COPD, fibrosis, or lung cancer are among the major causes of death Worldwide. Althoughthese are subjects of intense ...
The role of MYB28 and MYB29 in the tolerance of iron deficiency and the interplay between iron homeostasis and ammonium stress in Arabidopsis thaliana.
(2023-12-15)
El hierro y el nitrógeno son nutrientes cruciales para las plantas. El hierro está implicado en funciones vitales como la fotosíntesis y la síntesis de proteínas, pero a menudo es poco biodisponible en suelos con pH neutro ...
Study of human and mouse dermal fibroblast heterogeneity by single-cell RNA sequencing.
(2023-10-18)
The skin is a complex vital organ composed of several layers. The middle layer, the dermis, is mainly composed of fibroblasts that produce the extracellular matrix (ECM) providing structural support. Recent research using ...
Galectin-1 O-GlcNAcylation Controlled by Rac1/Muscle Glycogen Phosphorylase Pathway Modifies Microglial Responses to Amyloid b1-42 Peptide
(2022-03-31)
Esta tesis doctoral se basa en la descripción de los mecanismos moleculares que activan la migración y fagocitosis de la microglía en respuesta al péptido ß-amiloide, característico de la enfermedad de Alzheimer. Nuestros ...
Role of MCSF-activated microglia in amyloid-associated pathology
(2022-04-01)
Un evento clave que se desarrolla de forma temprana en la enfermedad de Alzheimer (EA) es el acúmulode las formas oligoméricas del péptido ß-amiloide (oAß) en el cerebro. En este estudio, hemosinvestigado el papel de la ...
Regulation of macrophage and preadipocyte proliferation and migration by C1P
(2022-03-25)
Chronic inflammatory diseases are the most significant cause of death in the world. Indeed, according to the World Health Organization (WHO), 3 out of 5 people die due to chronic inflammatory diseases such as stroke, chronic ...
Diagenetic research of factors influencing the performance of biomolecular investigations of human skeletal remains from Spanish Civil War graves.
(2023-03-09)
During the Spanish Civil War and the posterior dictatorship, a huge number of people disappeared during the war or in episodes of repression. A large number of victims remain unidentified. One of the main limitations of ...
Natural killer cell subset reconstitution after autologous hematopoietic stem cell transplantation in multiplemyeloma patients.
(2022-03-28)
Las células "natural killer" (NK) son un componente clave del sistema inmunitario innato y una de sus funciones es reconocer y eliminar células malignas. El trasplante autólogo de precursores hematopoyéticos (TASPE) es un ...
CRM1/XPO1 nukleotiko esportazio hartzailearen fisiopatologia: funtzio zelularraren eta ituratze terapeutikoaren azterketa
(2022-04-11)
CRM1 bestelako ehunka proteinaren, kargoren, nukleotik zitoplasmaranzko garraioa egikaritzen duen hartzailea da. Horretarako, CRM1ek poltsiko hidrofobiko bat du, zeinetara kargoen esportazio seinaleak, NESak, lotzen diren. ...
Reproductive constraints and gonadal alterations in fish locally exposed to pollutants: how life history shapes exposure
(2023-12-14)
La presencia global de contaminantes químicos y contaminantes en el medio acuático supone una amenaza para los organismos expuestos y esto recibe una atención cada vez mayor tanto por parte de la comunidad científica como ...