BackExaminar Artículos, Comunicaciones, Libros por departamento (eus.) "Farmakologia"
Now showing items 41-60 of 131
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Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age
; ; ; ; ; ; ; López de Jesús, Maider
; ; Montilla López, Alejandro ; Domercq García, María ; ; ; ; ; (MDPI, 2021-02-09)
first_page settings Open AccessArticle Effects of Platelet-Rich Plasma on Cellular Populations of the Central Nervous System: The Influence of Donor Age by Diego Delgado 1, Ane Miren Bilbao 2, Maider Beitia 1, Ane ... -
Efficacy of Acetylcholinesterase Inhibitors on Cognitive Function in Alzheimer's Disease. Review of Reviews
; ; Torrecilla Sesma, María; ; Bruzos Cidón, Cristina (MDPI, 2021-11-15)
Alzheimer’s disease (AD) is the most common form of dementia over the age of 65. It is estimated that 115.4 million people will be affected by AD by 2050. Acetylcholinesterase inhibitors (AChEI) are the only available and ... -
Efficacy of the combination of amphotericin B and echinocandins against Candida auris in vitro and in the Caenorhabditis elegans host model
Hernando Ortiz, Ainara; Eraso Barrio, María Elena ; Jauregizar Albonigamayor, Nerea ; ; ; Mateo Alesanco, Estibaliz (American Society of Microbiology, 2024-01)
The multidrug-resistant Candida auris is a global health emergency, being responsible for outbreaks of invasive candidiasis worldwide. Limited effective therapeutic options make it difficult to treat this emerging pathogen. ... -
Endocannabinoid 2-Arachidonoylglycerol Synthesis and Metabolism at Neuronal Nuclear Matrix Fractions Derived from Adult Rat Brain Cortex
; ; Barrondo Lacarra, Sergio; López de Jesús, Maider ; ; ; Goicolea Altuna, María Aranzazu ; (MDPI, 2023-02-05)
In this report, we describe the kinetics characteristics of the diacylglycerol lipase-α (DGLα) located at the nuclear matrix of nuclei derived from adult cortical neurons. Thus, using high-resolution fluorescence microscopy, ... -
Environmental enrichment shapes striatal spike-timing-dependent plasticity in vivo
(Nature, 2019-12-19)Behavioural experience, such as environmental enrichment (EE), induces long-term effects on learning and memory. Learning can be assessed with the Hebbian paradigm, such as spike-timing-dependent plasticity (STDP), which ... -
Evaluation of Fentanyl Disposition and Effects in Newborn Piglets as an Experimental Model for Human Neonates
(Public Library Science, 2014-03-04)Background: Fentanyl is widely used off-label in NICU. Our aim was to investigate its cerebral, cardiovascular and pulmonary effects as well as pharmacokinetics in an experimental model for neonates. Methods: Fentanyl ... -
Extracellular vesicles released by hair follicle and adipose mesenchymal stromal cells induce comparable neuroprotective and anti-inflammatory effects in primary neuronal and microglial cultures
; Igartua Olaechea, Manuela; Santos Vizcaíno, Edorta ; Hernández Martín, Rosa María (Elsevier, 2023-10)
Background aims Despite intensive research, to date, there is no effective treatment for neurodegenerative diseases. Among the different therapeutic approaches, recently, the use of extracellular vesicles (EVs) derived ... -
Fast and Efficient Neural Conversion of Human Hematopoietic Cells
; ; Bruzos Cidón, Cristina; ; ; ; ; ; ; ; ; ; Torrecilla Sesma, María ; ; (Cell Press, 2014-12-09)
Neurons obtained directly from human somatic cells hold great promise for disease modeling and drug screening. Available protocols rely on overexpression of transcription factors using integrative vectors and are often ... -
Fit-for-purpose based testing and validation of antibodies to amino- and carboxy-terminal domains of cannabinoid receptor 1
; ; Barrondo Lacarra, Sergio; ; ; ; López de Jesús, Maider ; ; Mato Santos, Susana ; ; ; Goicolea Altuna, María Aranzazu ; (Springer, 2021-11)
Specific and selective anti-CB1 antibodies are among the most powerful research tools to unravel the complex biological processes mediated by the CB1 receptor in both physiological and pathological conditions. However, low ... -
FOXP2 expression and gray matter density in the male brains of patients with schizophrenia
; ; ; ; ; ; Meana Martínez, José Javier; ; ; ; ; (Springer, 2021-06)
Common genetic variants ofFOXP2may contribute to schizophrenia vulnerability, but controversial results have been reported for this proposal. Here we evaluated the potential impact of the commonFOXP2rs2396753 polymorphism ... -
Frontal Cortex Lipid alterations During the Onset of Alzheimer's Disease
; ; ; Manuel Vicente, Iván; ; Rodríguez Puertas, Rafael ; (IOS Press, 2024-03-30)
Antecedentes: La enfermedad de Alzheimer (EA) esporádica es un trastorno neurodegenerativo de etiología desconocida. La EA familiar está asociada a mutaciones genéticas específicas. Una característica común de estas formas ... -
GAT-3 Dysfunction Generates Tonic Inhibition in Exter nal Globus Pallidus Neurons in Parkinsonian Rodents
(Cell Press, 2018-05-08)The external globus pallidus (GP) is a key GABAergic hub in the basal ganglia (BG) circuitry, a neuronal network involved in motor control. In Parkinson's disease (PD), the rate and pattern of activity of GP neurons are ... -
Glucocorticoid receptor dysregulation underlies 5-HT2AR-dependent synaptic and behavioral deficits in a mouse neurodevelopmental disorder model.
; Muguruza Millán, Carolina; ; ; Callado Hernando, Luis Felipe ; Meana Martínez, José Javier ; ; (Elsevier, 2022-11)
Prenatal environmental insults increase the risk of neurodevelopmental psychiatric conditions in the offspring. Structural modifications of dendritic spines are central to brain development and plasticity. Using maternal ... -
Handling and novel object recognition modulate fear response and endocannabinoid signaling in nucleus basalis magnocellularis
; ; ; Monge Benito, Sergio; ; Onandia Hinchado, Iban ; Manuel Vicente, Iván ; ; Rodríguez Puertas, Rafael (Wiley, 2022)
[EN] Storage of aversive memories is of utmost importance for survival, allowing animals to avoid upcoming similar stimuli. However, without reinforcement, the learned avoidance response gradually decreases over time. ... -
High S100B Levels Predict Antidepressant Response in Patients With Major Depression Even When Considering Inflammatory and Metabolic Markers
; ; Horrillo Furundarena, Igor; Cavero, Myriam ; ; ; Capuron, Lucile ; Meana Martínez, José Javier ; (Oxford University, 2022-06)
[EN] Background The relationship between antidepressant response and glial, inflammatory, and metabolic markers is poorly understood in depression. This study assessed the ability of biological markers to predict antidepressant ... -
Identification of BiP as a CB1 receptor- interacting protein that fine-tunes cannabinoid signaling in the mouse brain
Costas-Insua, Carlos; Moreno, Estefanía; Maroto, Irene B.; Ruiz-Calvo, Andrea; Bajo-Grañeras, Raquel; Martín-Gutiérrez, David; Díez Alarcia, Rebeca; Vilaró, M. Teresa; Cortés, Roser; García-Font, Nuria; Martín, Ricardo; Espina, Marc; Botta, Joaquín; Ginés, Silvia; McCormick, Peter J.; Sánchez-Prieto, José; Galve-Roperh, Ismael; Mengod, Guadalupe; Urigüen Echeverría, Leyre ; Marsicano, Giovanni; Bellocchio, Luigi; Canela, Enric I.; Casadó, Vicent; Rodríguez-Crespo, Ignacio; Guzmán, Manuel (The Society for Neuroscience, 2021-09-22)
Cannabinoids, the bioactive constituents of cannabis, exert a wide array of effects on the brain by engaging Type 1 cannabinoid receptor (CB1R). Accruing evidence supports that cannabinoid action relies on context-dependent ... -
Impairment of Serotonergic Transmission by the Antiparkinsonian Drug L-DOPA: Mechanisms and Clinical Implications
(Frontiers Media, 2017-09-12)The link between the anti-Parkinsonian drug L-3,4-dihydroxyphenylalanine (L-DOPA) and the serotonergic (5-HT) system has been long established and has received increased attention during the last decade. Most studies have ... -
Implementation of IFPTML Computational Models in Drug Discovery Against Flaviviridae Family
(ACS, 2024-03)The Flaviviridae family consists of single-stranded positive-sense RNA viruses, which contains the genera Flavivirus, Hepacivirus, Pegivirus, and Pestivirus. Currently, there is an outbreak of viral diseases caused by this ... -
In Vitro and In Vivo Activity of Citral in Combination with Amphotericin B, Anidulafungin and Fluconazole against Candida auris Isolates
; Guridi Cortaberria, Andrea; Jauregizar Albonigamayor, Nerea ; Eraso Barrio, María Elena ; ; (MDPI, 2023-06-06)
Candida auris is an emerging fungal pathogen responsible for hospital outbreaks of invasive candidiasis associated with high mortality. The treatment of these mycoses is a clinical challenge due to the high resistance ... -
In Vitro Antifungal Activity of Ibrexafungerp (SCY-078) Against Contemporary Blood Isolates From Medically Relevant Species of Candida: A European Study
; ; San Millán Gutiérrez, Rosario María; ; ; ; ; ; ; ; Vidal García, Matxalen ; ; Guridi Cortaberria, Andrea ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Jauregizar Albonigamayor, Nerea ; ; Eraso Barrio, María Elena (Frontiers Media, 2022-05)
BackgroundIbrexafungerp (SCY-078) is the newest oral and intravenous antifungal drug with broad activity, currently undergoing clinical trials for invasive candidiasis. ObjectiveThe aim of this study was to assess the in ...