BackExaminar Artículos, Comunicaciones, Libros por departamento (cas.) "Química orgánica II"
Now showing items 1-20 of 69
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Antibacterial and cytotoxic activities of new sphingolipids and other constituents isolated from Cissus incisa leaves
(Elsevier, 2020-08)Cissus incisa is used in traditional Mexican medicine to treat certain ailments, infectious or cancerous diseases. Excepting for our previous research, this species had no scientific reports validating its traditional use. ... -
Carbopalladation/Suzuki Coupling Cascade for the Generation of Quaternary Centers. Access to Pyrrolo[1,2-b]isoquinolines
(American Chemical Society, 2019-07-29)A convergent route to pyrrolo[1,2-b]isoquinolines with a quaternary center at C-10 has been developed, that implies a sequential Pd(0)-catalyzed carbopalladation followed by cross-coupling reaction with boronic acids. ... -
Carboxylates as Nucleophiles in the Enantioselective Ring-Opening of Formylcyclopropanes under IminiumIon Catalysis
; ; Uria Pujana, Uxue
; Carrillo Fernández, María Luisa ; ; ; Vicario Hernando, José Luis (Wiley-VCH, 2018-04-12)
In this work, carboxylic acids, which are typically regarded as poor nucleophiles, are demonstrated to be competent reagents to promote the ring-opening of formylcyclopropanes after activation of the latter through iminium ... -
Catalytic Enantioselective Cloke–Wilson Rearrangement
; Manzano, Rubén; Uria Pujana, Uxue ; Carrillo Fernández, María Luisa ; ; ; ; Vicario Hernando, José Luis (Wiley-VCH, 2018-05-09)
Racemic cyclopropyl ketones undergo enantioselective rearrangement to deliver the corresponding dihydrofurans in the presence of a chiral phosphoric acid as the catalyst. The reaction involves activation of the donor-acceptor ... -
Catalytic enantioselective domino Michael/transannular aldol reaction under bifunctional catalysis
; ; Carrillo Fernández, María Luisa; Uria Pujana, Uxue ; Prieto Aretxabaleta, Liher ; Manzano, Rubén ; Vicario Hernando, José Luis (Royal Society of Chemistry, 2020-09-28)
The enantioselective Michael reaction catalyzed by a bifunctional tertiary amine/squaramide has been used to trigger a Michael/transannular aldol cascade process that leads to densely substituted bicyclo[5.4.0]undecanes ... -
Catalytic Enantioselective Transannular Morita–Baylis–Hillman Reaction
; Manzano, Rubén; ; Carrillo Fernández, María Luisa ; Uria Pujana, Uxue ; Vicario Hernando, José Luis (American Chemical Society, 2019)
Catalytic and enantioselective approaches to transannular reactions are very limited and mostly are based on chiral Lewis acid catalyzed pericyclic reactions. In this report, we present an efficient and straightforward ... -
Catalytic Generation of Donor-Acceptor Cyclopropanes under N-Heterocyclic Carbene Activation and their Stereoselective Reaction with Alkylideneoxindoles
Prieto Aretxabaleta, Liher; ; Uria Pujana, Uxue ; ; Carrillo Fernández, María Luisa ; Vicario Hernando, José Luis (Wiley-VCH, 2017-04-10)
Formylcyclopropanes undergo activation in the presence of an N-heterocyclic carbene catalyst generating a donor-acceptor cyclopropane intermediate with the ability to undergo ring-opening followed by formal [4+2] ... -
Characterization and Optimization of the Alkaline Hydrolysis of Polyacrylonitrile Membranes
; ; Moreno Benítez, María Isabel; Vilas Vilela, José Luis (MDPI, 2019-11-08)
There is currently an increasing interest in the development of polyacrylonitrile (PAN)-based membranes with new and enhanced properties which are of special importance in the processes of pervaporation, purification, and ... -
Chiral Bronsted Acid-Catalyzed Enantioselective alpha-Amidoalkylation Reactions: A Joint Experimental and Predictive Study,
(Wiley VCH, 2016-12)Enamides with a free NH group have been evaluated as nucleophiles in chiral Bronsted acid-catalyzed enantioselective alpha-amidoalkylation reactions of bicyclic hydroxylactams for the generation of quaternary stereocenters. ... -
Complex Networks and Machine Learning: From Molecular to Social Sciences
(MDPI, 2019-11)Combining complex networks analysis methods with machine learning (ML) algorithms have become a very useful strategy for the study of complex systems in applied sciences. Noteworthy, the structure and function of such ... -
Cp*Co(III)-Catalyzed C−H Hydroarylation of Alkynes and Alkenes and Beyond: A Versatile Synthetic Tool
(ACS, 2020-09-15)The use of earth-abundant first-row transition metals, such as cobalt, in C−H activation reactions for the construction and functionalization of a wide variety of structures has become a central topic in synthetic ... -
Data Analysis in Chemistry and Bio-Medical Sciences
(MDPI, 2016-12-14)There is an increasing necessity for multidisciplinary collaborations in molecular science between experimentalists and theoretical scientists, as well as among theoretical scientists from different fields. One of the more ... -
Enantioselective Oxidative (4+3) Cycloadditions between Allenamides and Furans through Bifunctional Hydrogen-Bonding/Ion-Pairing Interactions
; Uria Pujana, Uxue; ; Prieto Aretxabaleta, Liher ; ; Carrillo Fernández, María Luisa ; Vicario Hernando, José Luis (Wiley-VCH, 2017-07-03)
BINOL-based N-trifluoromethanesulfonyl phosphoramides catalyze the enantioselective (4+3) cycloaddition between furans and oxyallyl cations, the latter being generated in situ by oxidation of allenamides. The chiral ... -
Enantioselective Synthesis of Tropanes: Brønsted Acid Catalyzed Pseudotransannular Desymmetrization
; Uria Pujana, Uxue; ; Carrillo Fernández, María Luisa ; ; ; Vicario Hernando, José Luis (Wiley-VCH, 2020-02-10)
The enantioselective synthesis of tropanols has been accomplished through chiral phosphoric acid catalyzed pseudotransannular ring opening of 1-aminocyclohept-4-ene-derived epoxides. The reaction proceeds together with the ... -
Favoring Trienamine Activation through Unconjugated Dienals: Organocatalytic Enantioselective Remote Functionalization of Alkenes
Prieto Aretxabaleta, Liher; ; Uria Pujana, Uxue ; ; Carrillo Fernández, María Luisa ; Vicario Hernando, José Luis (Wiley-VCH, 2014-01-29)
Unconjugated 2,5-dienals are more reactive substrates than the corresponding fully conjugated a,b,g,dunsaturated aldehydes towards organocatalytic activation through trienamine intermediates. This difference in ... -
Fluorinated carbohydrates as chemical probes formolecular recognition studies. Current statusand perspectives
Linclau, Bruno; Ardá, Ana; Reichardt, Niels Christian; Sollogoub, Matthieu; Unione, Luca; Vincent, Stéphane P.; Jiménez Barbero, Jesús (Royal Society of Chemistry, 2020-06-21)
This review provides an extensive summary of the effects of carbohydrate fluorination with regard to changes in physical, chemical and biological properties with respect to regular saccharides. The specific structural, ... -
Fluorinated Carbohydrates as Lectin Ligands: Simultaneous Screening of a Monosaccharide Library and Chemical Mapping by F-19 NMR Spectroscopy
Martínez, José Daniel; Manzano, Ana I.; Calviño, Eva; De Diego, Ana; Rodríguez de Francisco, Borja; Romanó, Cecilia; Oscarson, Stefan; Millet Aguilar-Galindo, Oscar; Gabius, Hans Joachim; Jiménez Barbero, Jesús; Cañada Vicinay, Francisco Javier (American Chemical Society, 2020-12-18)
Molecular recognition of carbohydrates is a key step in essential biological processes. Carbohydrate receptors can distinguish monosaccharides even if they only differ in a single aspect of the orientation of the hydroxyl ... -
Fluorine Labeling of Nanoparticles and In Vivo 19F Magnetic Resonance Imaging
Arango Rodríguez, Juan Manuel; Padró, Daniel; Blanco, Jorge; López Fernández, Sonia; Castellnou Arenas, Pilar; Villa Valverde, Palmira; Ruiz Cabello, Jesús; Martín Muñoz, Abraham; Carril García, Mónica (American Chemical Society, 2021-03-24)
Fluorinated nanoparticles have increasing applications, but they are still challenging to prepare, especially in the case of water-soluble fluorinated nanoparticles. Herein, a fluorine labeling strategy is presented that ... -
Galectin-4 N-Terminal Domain: Binding Preferences Toward A and B Antigens with Different Peripheral Core Presentations
Quintana García, Jon Imanol; Delgado, Sandra; Núñez Franco, Reyes; Cañada Vicinay, Francisco Javier; Jiménez Oses, Gonzalo; Jiménez Barbero, Jesús; Ardá, Ana (Frontiers Media, 2021-04-21)
The tandem-repeat Galectin-4 (Gal-4) contains two different domains covalently linked through a short flexible peptide. Both domains have been shown to bind preferentially to A and B histo blood group antigens with different ... -
Gene Prioritization, Communality Analysis, Networking and Metabolic Integrated Pathway to Better Understand Breast Cancer Pathogenesis
(Nature Publishing Group, 2018-11-12)Consensus strategy was proved to be highly efficient in the recognition of gene-disease association. Therefore, the main objective of this study was to apply theoretical approaches to explore genes and communities directly ...