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Revealing novel biomarkers for diagnosing chronic kidney disease in pediatric patients
(Nature, 2024)
Pediatric chronic kidney disease (CKD) is a clinical condition characterized by progressive renal function deterioration. CKD diagnosis is based on glomerular filtration rate, but its reliability is limited, especially at ...
Linked evolution of Paleocene sea floor relief and deep marine currents in the Subbetic Zone, southern Spain
(Elsevier, 2024-06)
Paleocene deposits of the Subbetic Zone (southern Spain) provide outstanding evidence of the influence of sea mountains on deep marine currents. This part of the Betic Cordillera External Zones corresponds to the distal ...
Controlling of the single domain wall propagation in magnetic microwires by magnetostatic interaction
(Elsevier, 2024-06)
Ultrafast magnetization switching through the single domain wall (DW) propagation has been reported in amorphous micrometric and submicrometric wires. However the performance of prospective devices utilizing DW propagation ...
Applying the Kolmogorov–Zurbenko filter followed by random forest models to 7Be observations in Spain (2006–2021)
(Elsevier, 2024-05)
n this study, we analysed 7Be weekly surface measurements from six Spanish laboratories from 2006 to 2021. The Kolmogorov–Zurbenko filter was applied to the six 7Be time series, and following an iterative process, the ...
Detailed dissection of UBE3A-mediated DDI1 ubiquitination.
(Frontiers, 2019-05-03)
The ubiquitin E3 ligase UBE3A has been widely reported to interact with the proteasome, but it is still unclear how this enzyme regulates by ubiquitination the different proteasomal subunits. The proteasome receptor DDI1 ...
Rigidified Bis(sulfonyl)ethylenes as Effective Michael Acceptors for Asymmetric Catalysis: Application to the Enantioselective Synthesis of Quaternary Hydantoins
(ACS, 2023-01-11)
The catalytic, enantio- and diastereoselective addition of
hydantoin surrogates II to “rigidified” vinylidene bis(sulfone) reagents is
developed, thus overcoming the inability of commonly employed β-
substituted vinylic ...
Brønsted Base-Catalyzed Enantioselective α-Functionalization of Carbonyl Compounds Involving π-Extended Enolates
(Wiley, 2023-11)
Chiral Brønsted base (BB) catalyzed asymmetric transformations constitute an important tool for synthesis. A meaningful fraction of these transformations proceeds through transiently generated enolate intermediates, which ...
alpha-Branched Ketone Dienolates: Base-Catalyzed Generation and Regio- and Enantioselective Addition Reactions
(Wiley-VCH, 2019-05-14)
In this study, the unique capacity of bifunctional Brønsted bases to generate α-branched ketone dienolates and control both site- and stereoselectivity of their addition reactions to representative classes of carbon ...
Catalytic Asymmetric α-Functionalization of α-Branched Aldehydes
(MDPI, 2023-03-16)
Aldehydes constitute a main class of organic compounds widely applied in synthesis. As such, catalyst-controlled enantioselective α-functionalization of aldehydes has attracted great interest over the years. In this context, ...
Reducing Negative Aging Stereotypes via Educational Intervention in Older People: A Randomized Controlled Study
(Sage, 2022-09-13)
Anti-ageism interventions traditionally target younger individuals. We analyzed the effect of an educational intervention that combined an infusion of aging content with videos to reduce negative stereotypes toward aging ...