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LUZP1 Controls Cell Division, Migration and Invasion Through Regulation of the Actin Cytoskeleton
(Frontiers Media, 2021-04-01)
LUZP1 is a centrosomal and actin cytoskeleton-localizing protein that regulates both ciliogenesis and actin filament bundling. As the cytoskeleton and cilia are implicated in metastasis and tumor suppression, we examined ...
Virion Structure and In Vitro Genome Release Mechanism of Dicistrovirus Kashmir Bee Virus
(American Society For Microbiology, 2021-06)
Infections with Kashmir bee virus (KBV) are lethal for honeybees and have been associated with colony collapse disorder. KBV and closely related viruses contribute to the ongoing decline in the number of honeybee colonies ...
The P. aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria
(Nature, 2022)
The type VI secretion system (T6SS) of Pseudomonas aeruginosa injects effector proteins into neighbouring competitors and host cells, providing a fitness advantage that allows this opportunistic nosocomial pathogen to ...
Identification of Androgen Receptor Metabolic Correlome Reveals the Repression of Ceramide Kinase by Androgens
(MDPI, 2021-08-26)
Prostate cancer (PCa) is one of the most prevalent cancers in men. Androgen receptor signaling plays a major role in this disease, and androgen deprivation therapy is a common therapeutic strategy in recurrent disease. ...
Quantification of Biomarker Functionality Predicts Patient Outcomes
(Springer Nature, 2021-05-11)
Implementation of a quantitative molecular imaging method (iFRET), which determines receptor–ligand interactions, has led to the finding that patients with a low extent of PD-1/PD-L1 interaction in metastatic NSCLC, and ...
Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts
(Elsevier, 2021-10)
BACKGROUND & AIMS: Colorectal cancer (CRC) shows variable response to immune checkpoint blockade, which can only partially be explained by high tumor mutational burden (TMB). We conducted an integrated study of the cancer ...
In Vitro Cellular Uptake Studies of Self-Assembled Fluorinated Nanoparticles Labelled with Antibodies
(MDPI, 2021-07-24)
Nanoparticles (NPs) functionalized with antibodies (Abs) on their surface are used in a wide range of bioapplications. Whereas the attachment of antibodies to single NPs to trigger the internalization in cells via ...
Molecular ruler mechanism and interfacial catalysis of the integral membrane acyltransferase PatA
(American Association for the Advancement of Science, 2021-10)
[EN]Glycolipids are prominent components of bacterial membranes that play critical roles not only in maintaining the structural integrity of the cell but also in modulating host-pathogen interactions. PatA is an essential ...
FORTIS: a Live-Cell Assay to Monitor AMPA Receptors Using pH-Sensitive Fluorescence Tags
(Nature, 2021-05-27)
The real-time live fluorescent monitoring of surface AMPA receptors (AMPARs) could open new opportunities for drug
discovery and phenotypic screening concerning neuropsychiatric disorders. We have developed FORTIS, a tool ...
Fluorine Labeling of Nanoparticles and In Vivo 19F Magnetic Resonance Imaging
(American Chemical Society, 2021-03-24)
Fluorinated nanoparticles have increasing applications, but they are still challenging to prepare, especially in the case of water-soluble fluorinated nanoparticles. Herein, a fluorine labeling strategy is presented that ...