BackExaminar Artículos por departamento (eus.) "Medikuntza"
Now showing items 21-40 of 175
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Association between CASP8-652 6N Del Polymorphism (rs3834129) and Colorectal Cancer Risk: Results from a Multi-Centric Study
Pardini, Barbara; Verderio, Paolo; Pizzamiglio, Sara; Nici, Carmela; Maiorana, Maria Valeria; Naccarati, Alessio; Vodickova, Ludmila; Vymetalkova, Veronika; Veneroni, Silvia; Daidone, Maria Grazia; Ravagnani, Fernando; Bianchi, Tiziana; Bujanda Fernández de Pierola, Luis
; Carracedo, Angel; Castells, Antoni; Ruiz Ponte, Clara; Morreau, Hans; Howarth, Kimberley; Jones, Angela; Castellví-Bel, Sergi; Li, Li; Tomlinson, Ian; Van Wezel, Tom; Vodicka, Pavel; Radice, Paolo; Peterlongo, Paolo; EPICOLON Consortium (Public Library Science, 2014-01)
The common 2652 6N del variant in the CASP8 promoter (rs3834129) has been described as a putative low-penetrance risk factor for different cancer types. In particular, some studies suggested that the deleted allele (del) ... -
Associations between Dietary Polyphenols and Type 2 Diabetes in a Cross-Sectional Analysis of the PREDIMED-Plus Trial: Role of Body Mass Index and Sex
; ; ; ; ; ; ; ; ; ; Alonso Gómez, Ángel María; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (MDPI, 2019-11-08)
Overweight and obesity are important risk factors for type 2 diabetes (T2D). Moving towards healthier diets, namely, diets rich in bioactive compounds, could decrease the odds of suffering T2D. However, those individuals ... -
Beneficial effect of ursodeoxycholic acid in patients with acyl-CoA oxidase 2 (ACOX2) deficiency-associated hypertransaminasemia
; ; ; ; ; ; ; ; Bujanda Fernández de Pierola, Luis; ; ; ; ; ; ; ; ; ; ; ; ; ; (Wiley, 2022-11)
Background and Aims: A variant (p.Arg225Trp) of peroxisomal acyl-CoA oxidase 2 (ACOX2), involved in bile acid (BA) side-chain shortening, has been associated with unexplained persistent hypertransaminasemia and ... -
Brain connectivity and cognitive functioning in individuals six months after multiorgan failure
(Elsevier, 2019-12)Abstract Multiorgan failure (MOF) is a life-threating condition that affects two or more systems of organs not involved in the disorder that motivates admission to an Intensive Care Unit (ICU). Patients who survive MOF ... -
Broad Phenotypes of Disorders/Differences of Sex Development in MAMLD1 Patients Through Oligogenic Disease
Flueck, Christa E.; Audi, Laura; Fernández Cancio, Mónica; Sauter, Kay Sara; Martínez de la Piscina Martín, Idoia; Castaño González, Luis Antonio; Esteva, Isabel; Camats, Nuria (Frontiers Media, 2019-08-29)
Disorders/differences of sex development (DSD) are the result of a discordance between chromosomal, gonadal, and genital sex. DSD may be due to mutations in any of the genes involved in sex determination and development ... -
Burkitt-like lymphoma with 11q aberration: a germinal center-derived lymphoma genetically unrelated to Burkitt lymphoma
(Ferrata Storti Foundation, 2019-08-31)Burkitt-like lymphoma with 11q aberration is characterized by pathological features and gene expression profile resembling those of Burkitt lymphoma but lacks the MYC rearrangement and carries an 11q-arm aberration with ... -
Cholangiocarcinoma 2020: the next horizon in mechanisms and management
Bañales Asurmendi, Jesús María; ; ; ; ; ; ; ; Andersen, Jesper B.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Springer Nature, 2020-06-30)
[EN] Cholangiocarcinoma (CCA) includes a cluster of highly heterogeneous biliary malignant tumours that can arise at any point of the biliary tree. Their incidence is increasing globally, currently accounting for ~15% ... -
Cholangiocarcinoma landscape in Europe: Diagnostic, prognostic and therapeutic insights from the ENSCCA Registry
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; Andersen, Jesper B.; ; ; Bujanda Fernández de Pierola, Luis; ; ; ; Bañales Asurmendi, Jesús María (Elsevier, 2022-05)
Background & Aims: Cholangiocarcinoma (CCA) is a rare and heterogeneous biliary cancer, whose incidence and related mortality is increasing. This study investigates the clinical course of CCA and subtypes (intrahepatic ... -
Clinical correlates of anti-SARS-CoV-2 antibody profiles in Spanish COVID-19 patients from a high incidence region
Markewitz, Robert; Torge, Antje; Wandinger, Klaus-Peter; Pauli, Daniela; Franke, Andre; Bujanda Fernández de Pierola, Luis; Marimón Ortiz de Zarate, José María; Bañales Asurmendi, Jesús María ; Gutiérrez Stampa, María Angeles; Nafría, Beatriz; Junker, Ralf (Nature, 2021-02-23)
Laboratory testing for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) consists of two pillars: the detection of viral RNA via rt-PCR as the diagnostic gold standard in acute cases, and the detection of ... -
Clinical features and outcomes of Streptococcus anginosus group infective Endocarditis: a multicenter matched cohort study
(Oxford University Press, 2021-03-29)[EN] Background. Although Streptococcus anginosus group (SAG) endocarditis is considered a severe disease associated with abscess formation and embolic events, there is limited evidence to support this assumption. Methods. ... -
Colorectal Cancer Genetic Variants Are Also Associated with Serrated Polyposis Syndrome Susceptibility
Arnau Collell, Coral; Soares de Lima, Yasmin; Díaz Gay, Marcos; Muñoz, Jenifer; Carballal, Sabela; Bonjoch, Laia; Moreira, Leticia; Lozano, Juan José; Ocaña, Teresa; Cuatrecasas, Miriam; Díaz de Bustamante, Aranzazu; Castells, Antoni; Capella, Gabriel; Bujanda Fernández de Pierola, Luis; Cubiella, Joaquín; Rodríguez Alcalde, Daniel; Balaguer, Francesc; Ruiz Ponte, Clara; Valle, Laura; Moreno, Víctor; Castellví Bel, Sergi (BMJ Publishing Group, 2020-10)
Background Serrated polyposis syndrome (SPS) is a clinical entity characterised by large and/ormultiple serrated polyps throughout the colon and increased risk for colorectal cancer (CRC). The basis for SPS genetic ... -
Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy
Murcia, Oscar; Juárez, Míriam; Rodríguez Soler, María; Hernández Illán, Eva; Giner Calabuig, Mar; Alustiza, Miren; Egoavil, Cecilia; Castillejo, Adela; Alenda, Cristina; Barberá, Víctor; Mangas Sanjuan, Carolina; Yuste, Ana; Bujanda Fernández de Pierola, Luis; Clofent, Joan; Andreu, Montserrat; Castells, Antoni; Llor, Xavier; Zapater, Pedro; Jover, Rodrigo (Public Library of Science, 2018-09-06)
Objective The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate ... -
Colorectal Cancer Survival in 50- to 69-Year-Olds after Introducing the Faecal Immunochemical Test
Gutierrez Stampa, María Angeles; Aguilar Gama, Vanessa; Sarasqueta Eizaguirre, Cristina; Cubiella, Joaquín; Portillo Villares, María Isabel; Bujanda Fernández de Pierola, Luis (MDPI, 2020-08-25)
Population screening has improved early diagnosis of colorectal cancer (CRC). Nonetheless, most cases are diagnosed in symptomatic patients. Faecal immunochemical testing has been recommended for assessing patients with ... -
Consumption of Caffeinated Beverages and Kidney Function Decline in an Elderly Mediterranean Population with Metabolic Syndrome
; ; ; ; ; ; ; ; Alonso Gómez, Ángel María; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Nature, 2021-03-31)
It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We investigated the associations between coffee, tea, or caffeine intake and ... -
Contribution of cardio-vascular risk factors to depressive status in the PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
; ; ; ; ; ; ; ; Alonso Gómez, Ángel María; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (Public Library Science, 2022-04-13)
BACKGROUND: Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive ... -
Correlative super-resolution fluorescence and electron microscopy using conventional fluorescent proteins in vacuo
Peddie, Christopher J.; Domart, Marie-Charlotte; Snetkov, Xenia; O'Toole, Peter; Larijani, Banafshé; Way, Michael; Cox, Susan; Collinson, Lucy M. (Elsevier, 2017-08)
Super-resolution light microscopy, correlative light and electron microscopy, and volume electron microscopy are revolutionising the way in which biological samples are examined and understood. Here, we combine these ... -
Current Approaches for Predicting a Lack of Response to Anti-EGFR Therapy in KRAS Wild-Type Patients
Er, Tze-Kiong; Chen, Chih-Chieh; Bujanda Fernández de Pierola, Luis; Herreros Villanueva, Marta (Hindawi Publishing, 2014)
Targeting epidermal growth factor receptor (EGFR) has been one of the most effective colorectal cancer strategies. Anti-EGFR antibodies function by binding to the extracellular domain of EGFR, preventing its activation, ... -
Dairy Product Consumption and Changes in Cognitive Performance: Two-Year Analysis of the PREDIMED-Plus Cohort
Alonso Gómez, Ángel María; (Wiley, 2022-07)
[EN] Scope Dairy consumption has been suggested to impact cognition; however, evidence is limited and inconsistent. This study aims to longitudinally assess the association between dairy consumption with cognitive changes ... -
Detailed stratified GWAS analysis for severe COVID-19 in four European populations.
(Oxford University Press, 2022-12)Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease ... -
Determinants of Participation in a Post-Hospitalization Physical Exercise Program for Older Adults
Urquiza Abaunza, Miriam; Echeverria Garay, Iñaki ; ; Amasene Ugalde, María ; Labayen Goñi, Idoya ; ; ; ; Irazusta Astiazaran, Jon (BioMed Central, 2020-10-16)
Background: Older patients often experience a decline in physical function and cognitive status after hospitalization. Although interventions involving physical exercise are effective in improving functional performance, ...