Search
Now showing items 51-60 of 108
Annual Research Review: Prevention of Psychosis in Adolescents - Systematic Review and Meta-Analysis of Advances in Detection, Prognosis and Intervention
(Wiley, 2021-05)
Background The clinical high-risk state for psychosis (CHR-P) paradigm has facilitated the implementation of psychosis prevention into clinical practice; however, advancements in adolescent CHR-P populations are less ...
Implementing Precision Psychiatry: a Systematic Review of Individualized Prediction Models for Clinical Practice
(Oxford University Press, 2021-03-16)
BACKGROUND: The impact of precision psychiatry for clinical practice has not been systematically appraised. This study aims to provide a comprehensive review of validated prediction models to estimate the individual risk ...
Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response
(MDPI, 2020-08-24)
Sephin1 is a derivative of guanabenz that inhibits the dephosphorylation of the eukaryotic initiation factor 2 alpha (eIF2α) and therefore may enhance the integrated stress response (ISR), an adaptive mechanism against ...
Brain White Matter Correlates of Creativity in Schizophrenia: A Diffusion Tensor Imaging Study
(Frontiers Media, 2020-06)
The relationship between creativity and psychopathology has been a controversial research topic for decades. Specifically, it has been shown that people with schizophrenia have an impairment in creative performance. However, ...
Expression and Function of GABA Receptors in Myelinating Cells
(Frontiers Media, 2020-08-21)
Myelin facilitates the fast transmission of nerve impulses and provides metabolic support to axons. Differentiation of oligodendrocyte progenitor cells (OPCs) and Schwann cell (SC) precursors is critical for myelination ...
Subsynaptic Distribution, Lipid Raft Targeting and G Protein-Dependent Signalling of the Type 1 Cannabinoid Receptor in Synaptosomes from the Mouse Hippocampus and Frontal Cortex
(MDPI, 2021-11-16)
Numerous studies have investigated the roles of the type 1 cannabinoid receptor (CB1) in glutamatergic and GABAergic neurons. Here, we used the cell-type-specific CB1 rescue model in mice to gain insight into the organizational ...
The Endocannabinoid System in Glial Cells and Their Profitable Interactions to Treat Epilepsy: Evidence from Animal Models
(MDPI, 2021-12-08)
Epilepsy is one of the most common neurological conditions. Yearly, five million people are diagnosed with epileptic-related disorders. The neuroprotective and therapeutic effect of (endo)cannabinoid compounds has been ...
Current Techniques for Investigating the Brain Extracellular Space
(Frontiers Media, 2020-10-14)
The brain extracellular space (ECS) is a continuous reticular compartment that lies between the cells of the brain. It is vast in extent relative to its resident cells, yet, at the same time the nano- to micrometer dimensions ...
Neurodegeneration Trajectory in Pediatric and Adult/Late DM1: a Follow-up MRI Study Across a Decade
(Wiley, 2020-10)
Objective: To characterize the progression of brain structural abnormalities in adults with pediatric and adult/late onset DM1, as well as to examine the potential predictive markers of such progression.
Methods: 21 DM1 ...
Delta(9)-Tetrahydrocannabinol Promotes Oligodendrocyte Development and CNS Myelination in Vivo
(Wiley, 2021-03)
Delta(9)-Tetrahydrocannabinol (THC), the main bioactive compound found in the plantCannabis sativa, exerts its effects by activating cannabinoid receptors present in many neural cells. Cannabinoid receptors are also ...