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Visual Programming Environments for Object Oriented Programming: Acceptance and Effects on Student Motivation
(IEEE, 2017-08-07)
This paper presents an experiment in which visual programming environments have been used in programming courses aiming at helping students to acquire the competencies of a course on object-oriented programming. This paper ...
G protein-membrane interactions II: Effect of G Protein-linked Lipids on Membrane Structure and G Protein-membrane Interactions
(Elsevier, 2017-07-03)
[EN] G proteins often bear myristoyl, palmitoyl and isoprenyl moieties, which favor their
association with the membrane and their accumulation in G Protein Coupled Receptor-rich
microdomains. These lipids influence the ...
Size-effect and scaling power-law for superelasticity in Shape Memory Alloys at the nano-scale
(Macmillan Publishers Limited, part of Springer Nature., 2017-05-29)
Shape-memory alloys capable of a superelastic stress-induced phase transformation and a high displacement actuation have promise for applications in micro-electromechanical systems for wearable healthcare and flexible ...
Conformational stabilization as a strategy to prevent nucleophosmin mislocalization in leukemia
(Nature Research, 2017-10-24)
Nucleophosmin (NPM) is a nucleolar protein involved in ribosome assembly and cell homeostasis. Mutations in the C-terminal domain of NPM that impair native folding and localization are associated with acute myeloid leukemia ...
Shortcuts to adiabaticity in optical waveguides using fast quasiadiabatic dynamics
(Optica Publishing Group, 2017-01-03)
We propose a fast quasiadiabatic approach to the design of optical waveguide devices. This approach distributes the system adiabaticity homogeneously over the device length, thus providing a shortcut to adiabaticity at a ...
Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge
(Nature Publishing, 2017-11-15)
Specific protein-lipid interactions lead to a gradual recruitment of AuTophaGy-related (ATG) proteins to the nascent membrane during autophagosome (AP) formation. ATG3, a key protein in the movement of LC3 towards the ...
Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: implications for therapy
(Elsevier, 2017-06-19)
Adult polyglucosan body disease (APBD) is a neurological disorder characterized by adult-onset neurogenic bladder, spasticity, weakness, and sensory loss. The disease is caused by aberrant glycogen branching enzyme (GBE) ...
Multiple-Criteria Decision-Making Tool for Local Governments to Evaluate the Global and Local Sustainability of Transportation Systems in Urban Areas: Case Study
(ASCE, 2017-10-24)
Efficient management of urban transportation systems is a challenge for any local government that wishes to improve public wellbeing and comfort. With that end in mind, this paper proposes a tool for decision making and ...
MTHFR Polymorphisms In Childhood Acute lymphoblastic Leukemia: Influence On Methotrexate Therapy
(Dove Medical Press LTD, 2017)
Methotrexate (MTX) is an important component in the therapy used to treat childhood
acute lymphoblastic leukemia (ALL). Methylenetetrahydrofolate reductase (MTHFR) is a key
enzyme for MTX pharmacokinetics. Two single-nucleotide ...
Confirmation of involvement of new variants at CDKN2A/B in pediatric acute lymphoblastic leukemia susceptibility in the Spanish population
(Public Library Science, 2017-05-08)
The locus CDKN2A/B (9p21.3), which comprises the tumor suppressors genes CDKN2A and CDKN2B and the long noncoding RNA (lncRNA) known as ANRIL (or CDKN2B-AS), was associated with childhood acute lymphoblastic leukemia (ALL) ...