dc.contributor.author | Oliveira da Cruz, Jose F. | |
dc.contributor.author | Busquets Garcia, Arnau | |
dc.contributor.author | Zhao, Zhe | |
dc.contributor.author | Varilh, Marjorie | |
dc.contributor.author | Lavanco, Gianluca | |
dc.contributor.author | Bellocchio, Luigi | |
dc.contributor.author | Robin, Laurie | |
dc.contributor.author | Cannich, Astrid | |
dc.contributor.author | Julio Kalajzić, Francisca | |
dc.contributor.author | Lesté Lasserre, Thierry | |
dc.contributor.author | Maître, Marlène | |
dc.contributor.author | Drago, Filippo | |
dc.contributor.author | Marsicano, Giovanni | |
dc.contributor.author | Soria Gómez, Edgar | |
dc.date.accessioned | 2020-12-17T13:11:42Z | |
dc.date.available | 2020-12-17T13:11:42Z | |
dc.date.issued | 2020-08-18 | |
dc.identifier.citation | Cell Reports 32(7) : (2020) // Article ID 108046 | es_ES |
dc.identifier.issn | 2211-1247 | |
dc.identifier.uri | http://hdl.handle.net/10810/49144 | |
dc.description.abstract | A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid receptor (CB1R)-expressing hippocampal intemeurons determines episodic-like memory consolidation by linking dopamine D-1 receptor (D1R) signaling to GABAergic transmission. Mice lacking CB(1)Rs in D-1-positive cells (D-1-CB1-KO) display impairment in long-term, but not short-term, novel object recognition memory (NOR). Re-expression of CB(1)Rs in hippocampal D1R-positive cells rescues this NOR deficit. Learning induces an enhancement of in vivo hippocampal long-term potentiation (LTP), which is absent in mutant mice. CB1R-mediated NOR and the associated LTP facilitation involve local control of GABAergic inhibition in a D-1-dependent manner.
This study reveals that hippocampal CB1R-/D1R-expressing interneurons control NOR memory, identifying a mechanism linking the diversity of hippocampal interneurons to specific behavioral outcomes. | es_ES |
dc.description.sponsorship | We thank Delphine Gonzales, Nathalie Aubailly, and the personnel of the Animal Facilities of the NeuroCentre Magendie for mouse care. We thank the Biochemistry Platform of Bordeaux NeuroCampus and the members of Marsicano's lab for useful discussions. This work was funded by INSERM; the European Research Council (Endofood ERC-2010-StG-260515, CannaPreg ERC-2014-PoC-640923, and MiCaBra ERC-2017-AdG-786467 to G.M.); Fondation pour la Recherche Medicale (FRM; DRM20101220445 to G.M. and DT20160435664 to J.F.O.d.C.); the Human Frontiers Science Program, Region Aquitaine, Agence Nationale de la Recherche (ANR; NeuroNutriSens ANR-13-BSV4-0006, ORUPS ANR-16-CE37-0010-01, and CaCoVi ANR-18-CE160001-02 to G.M.); BRAIN ANR-10-LABX-0043 (to G.M.); NIH/NIDA (1R21DA037678-01); the European Regional Development Fund; the European Union Horizon 2020 Research and Innovation Program (grant agreement 686009); French State/Agence Nationale de la Recherche/IdEx (ANR-10-IDEX-03-02), Eu-Fp7 (FP7-PEOPLE-2013-IEF-623638), and MINECO/AEI (RYC-2017-21776) (to A.B.-G.); FRM (ARF20140129235 to L.B.); and Ikerbasque (The Basque Foundation for Science) and MINECO (Ministerio de Economi ' a y Competitividad) PGC2018-093990-A-I00 (MICIU/AEI/FEDER, UE) (to E.S.-G.). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cell Press | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/686009 | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/623638 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/RYC-2017-21776 | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/PGC2018-093990-A-I00 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | CB1 cannabinoid receptors | es_ES |
dc.subject | long-term potentiation | es_ES |
dc.subject | episodic memory | es_ES |
dc.subject | dopamine | es_ES |
dc.subject | neurons | es_ES |
dc.subject | CA1 | es_ES |
dc.subject | LTP | es_ES |
dc.subject | information | es_ES |
dc.subject | inhibition | es_ES |
dc.subject | modulation | es_ES |
dc.title | Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | 2020 The Author(s).1This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | es_ES |
dc.rights.holder | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S2211124720310317?via%3Dihub | es_ES |
dc.identifier.doi | 10.1016/j.celrep.2020.108046 | |
dc.departamentoes | Neurociencias | es_ES |
dc.departamentoeu | Neurozientziak | es_ES |