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dc.contributor.authorCamarero Espinosa, Sandra
dc.contributor.authorMoroni, Lorenzo
dc.identifier.citationNature Communications 12(1) : (2021) // Article ID 1031es_ES
dc.description.abstractThe application of physical stimuli to cell cultures has shown potential to modulate multiple cellular functions including migration, differentiation and survival. However, the relevance of these invitro models to future potential extrapolation invivo depends on whether stimuli can be applied "externally", without invasive procedures. Here, we report on the fabrication and exploitation of dynamic additive-manufactured Janus scaffolds that are activated on-command via external application of ultrasounds, resulting in a mechanical nanovibration that is transmitted to the surrounding cells. Janus scaffolds were spontaneously formed via phase-segregation of biodegradable polycaprolactone (PCL) and polylactide (PLA) blends during the manufacturing process and behave as ultrasound transducers (acoustic to mechanical) where the PLA and PCL phases represent the active and backing materials, respectively. Remote stimulation of Janus scaffolds led to enhanced cell proliferation, matrix deposition and osteogenic differentiation of seeded human bone marrow derived stromal cells (hBMSCs) via formation and activation of voltage-gated calcium ion channelses_ES
dc.description.sponsorshipThe authors acknowledge the Texas A&M Health Science Center College of Medicine Institute for Regenerative Medicine at Scott & White who isolated and provided the cells through a grant from NCRR of the NIH (Grant #P40RR017447). The authors acknowledge the financial support from the European Commission under the ERC starting grant “Cell Hybridge” of the Horizon2020 framework program (Grant # 637308).es_ES
dc.subjectphysical stimulies_ES
dc.subjectcell cultureses_ES
dc.subjectinvitro modelses_ES
dc.subjectJanus scaffoldses_ES
dc.subjectmechanical nanovibrationes_ES
dc.subjectsurrounding cellses_ES
dc.titleJanus 3D Printed Dynamic Scaffolds for Nanovibration-Driven Bone Regenerationes_ES
dc.rights.holderThis article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0)es_ES
dc.rights.holderAtribución 3.0 España*
dc.contributor.funderEuropean Commission
dc.departamentoesCiencia y tecnología de polímeroses_ES
dc.departamentoeuPolimeroen zientzia eta teknologiaes_ES

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This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0)
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