Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Patients with Resected Perihilar Cholangiocarcinoma: The ENSCCA Registry
dc.contributor.author | Nooijen, Lynn E. | |
dc.contributor.author | Bañales Asurmendi, Jesús María | |
dc.contributor.author | De Boer, Marieke T. | |
dc.contributor.author | Braconi, Chiara | |
dc.contributor.author | Folseraas, Trine | |
dc.contributor.author | Forner, Alejandro | |
dc.contributor.author | Holowko, Waclaw | |
dc.contributor.author | Hoogwater, Frederik J. H. | |
dc.contributor.author | Klümpen, Heinz-Josef | |
dc.contributor.author | Groot Koerkamp, Bas | |
dc.contributor.author | Lamarca, Angela | |
dc.contributor.author | Lacasta, Adelaida | |
dc.contributor.author | López López, Flora | |
dc.contributor.author | Izquierdo Sánchez, Laura | |
dc.contributor.author | Scheiter, Alexander | |
dc.contributor.author | Utpatel, Kirsten | |
dc.contributor.author | Swijnenburg, Rutger-Jan | |
dc.contributor.author | Kazemier, Geert | |
dc.contributor.author | Erdmann, Joris I. | |
dc.date.accessioned | 2022-05-31T10:07:08Z | |
dc.date.available | 2022-05-31T10:07:08Z | |
dc.date.issued | 2022-05-12 | |
dc.identifier.citation | Cancers 14(10) : (2022) // Article ID 2389 | es_ES |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | http://hdl.handle.net/10810/56803 | |
dc.description.abstract | Background: Lymph node metastasis and positive resection margins have been reported to be major determinants of overall survival (OS) and poor recurrence-free survival (RFS) for patients who underwent resection for perihilar cholangiocarcinoma (pCCA). However, the prognostic value of positive lymph nodes independently from resection margin status on OS has not been evaluated. Methods: From the European Cholangiocarcinoma (ENSCCA) registry, patients who underwent resection for pCCA between 1994 and 2021 were included in this retrospective cohort study. The primary outcome was OS stratified for resection margin and lymph node status. The secondary outcome was recurrence-free survival. Results: A total of 325 patients from 11 different centers and six European countries were included. Of these, 194 (59.7%) patients had negative resection margins. In 113 (34.8%) patients, positive lymph nodes were found. Lymph node status, histological grade, and ECOG performance status were independent prognostic factors for survival. The median OS for N0R0, N0R1, N+R0, and N+R1 was 38, 30, 18, and 12 months, respectively (p < 0.001). Conclusion: These data indicate that in the presence of positive regional lymph nodes, resection margin status does not determine OS or RFS in patients with pCCA. Achieving negative margins in patients with positive nodes should not come at the expense of more extensive surgery and associated higher mortality. | es_ES |
dc.description.sponsorship | The ENSCCA Registry is completely funded by the European Association for the Study of the Liver (EASL; Registry grant awards 2016 and 2019 to J.M.B.), Incyte Bioscience International Sàrl (grant award 2020 to J.M.B.) and European Union’s Horizon 2020 Research and Innovation Program (grant number 825510, ESCALON: to J.M.B. and A.L.). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/825510 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | perihilar cholangiocarcinoma | es_ES |
dc.subject | lymph nodes | es_ES |
dc.subject | resection margin | es_ES |
dc.subject | overall survival | es_ES |
dc.subject | recurrence-free survival | es_ES |
dc.title | Impact of Positive Lymph Nodes and Resection Margin Status on the Overall Survival of Patients with Resected Perihilar Cholangiocarcinoma: The ENSCCA Registry | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.date.updated | 2022-05-27T13:37:08Z | |
dc.rights.holder | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | es_ES |
dc.relation.publisherversion | https://www.mdpi.com/2072-6694/14/10/2389 | es_ES |
dc.identifier.doi | 10.3390/cancers14102389 | |
dc.contributor.funder | European Commission | |
dc.departamentoes | Medicina | |
dc.departamentoeu | Medikuntza |
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