Development of Geometry-Controlled All-Orthogonal BODIPY Trimers for Photodynamic Therapy and Phototheragnosis
Ikusi/ Ireki
Data
2022-05Egilea
Prieto Castañeda, Alejandro
García Garrido, Fernando
Díaz Norambuena, Carolina
Escriche Navarro, Blanca
García Fernández, Alba
García Moreno, Inmaculada
Martínez Máñez, Ramón
de la Moya, Santiago
Agarrabeitia, Antonia R.
Ortiz, María J.
Organic Letters 24(20) : 3636-3641 (2022)
Laburpena
We have established an easy synthetic protocol for selectively developing all-orthogonal BODIPY trimers with unprece-dented geometries on the basis of selecting methyl oxidation versus electrophilic formylation of key dimeric precursors. Photophysical characterization together with biological assays unraveled the most suitable BODIPY-BODIPY geometrical arrangements within the trimer, forcing them to serve as molecular platforms for the development of new, advanced heavy-atom-free photosensitizers for photodynamic therapy and phototheragnosis.