dc.contributor.author | Maestro Burzaco, Aitor | |
dc.contributor.author | Martín Encinas, Endika | |
dc.contributor.author | Alonso Pérez, Concepción Estibaliz | |
dc.contributor.author | Martínez de Marigorta Izaga, Edorta | |
dc.contributor.author | Rubiales Alcaine, María Gloria | |
dc.contributor.author | Vicario Hernando, Javier | |
dc.contributor.author | Palacios Gambra, Francisco Javier | |
dc.date.accessioned | 2024-04-10T15:04:44Z | |
dc.date.available | 2024-04-10T15:04:44Z | |
dc.date.issued | 2018-09-15 | |
dc.identifier.citation | European Journal of Medicinal Chemistry 158 : 874-883 (2018) | es_ES |
dc.identifier.issn | 0223-5234 | |
dc.identifier.uri | http://hdl.handle.net/10810/66601 | |
dc.description.abstract | An efficient synthetic methodology for the preparation of phosphorus substituted bis-(3-indolyl)methane through a double nucleophilic addition of indole derivatives to an in situ generated α-iminophosphonate is reported. In addition, bis-(3-indolyl)methane substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell lines A549 (carcinomic human alveolar basal epithelial cell) and SKOV03 (human ovarian carcinoma). | es_ES |
dc.description.sponsorship | Financial support by Ministerio de Economía, Industria y Competividad (MINECO, CTQ-2015-67871R) and Gobierno Vasco (GV, IT 992-16) is gratefully acknowledged. We also thank SGIker (UPV/EHU) technical support for NMR spectra (MINECO, GV/EJ, and European Social Found). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/CTQ-2015-67871R | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | indole | es_ES |
dc.subject | bis-(3-indolyl)methanes | es_ES |
dc.subject | BIMs | es_ES |
dc.subject | phosphonate | es_ES |
dc.subject | antiproliferative effect | es_ES |
dc.title | Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | © 2018 Elsevier Masson SAS under CC BY-NC-ND license | es_ES |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0223523418307839 | es_ES |
dc.identifier.doi | 10.1016/j.ejmech.2018.09.011 | |
dc.departamentoes | Química orgánica I | es_ES |
dc.departamentoeu | Kimika organikoa I | es_ES |