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dc.contributor.authorMaestro Burzaco, Aitor
dc.contributor.authorMartín Encinas, Endika
dc.contributor.authorAlonso Pérez, Concepción Estibaliz ORCID
dc.contributor.authorMartínez de Marigorta Izaga, Edorta ORCID
dc.contributor.authorRubiales Alcaine, María Gloria ORCID
dc.contributor.authorVicario Hernando, Javier ORCID
dc.contributor.authorPalacios Gambra, Francisco Javier ORCID
dc.date.accessioned2024-04-10T15:04:44Z
dc.date.available2024-04-10T15:04:44Z
dc.date.issued2018-09-15
dc.identifier.citationEuropean Journal of Medicinal Chemistry 158 : 874-883 (2018)es_ES
dc.identifier.issn0223-5234
dc.identifier.urihttp://hdl.handle.net/10810/66601
dc.description.abstractAn efficient synthetic methodology for the preparation of phosphorus substituted bis-(3-indolyl)methane through a double nucleophilic addition of indole derivatives to an in situ generated α-iminophosphonate is reported. In addition, bis-(3-indolyl)methane substrates showed in vitro cytotoxicity, inhibiting the growth of carcinoma human tumor cell lines A549 (carcinomic human alveolar basal epithelial cell) and SKOV03 (human ovarian carcinoma).es_ES
dc.description.sponsorshipFinancial support by Ministerio de Economía, Industria y Competividad (MINECO, CTQ-2015-67871R) and Gobierno Vasco (GV, IT 992-16) is gratefully acknowledged. We also thank SGIker (UPV/EHU) technical support for NMR spectra (MINECO, GV/EJ, and European Social Found).es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/CTQ-2015-67871Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectindolees_ES
dc.subjectbis-(3-indolyl)methaneses_ES
dc.subjectBIMses_ES
dc.subjectphosphonatees_ES
dc.subjectantiproliferative effectes_ES
dc.titleSynthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivativeses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2018 Elsevier Masson SAS under CC BY-NC-ND licensees_ES
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0223523418307839es_ES
dc.identifier.doi10.1016/j.ejmech.2018.09.011
dc.departamentoesQuímica orgánica Ies_ES
dc.departamentoeuKimika organikoa Ies_ES


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© 2018 Elsevier Masson SAS under CC BY-NC-ND license
Except where otherwise noted, this item's license is described as © 2018 Elsevier Masson SAS under CC BY-NC-ND license