UPV-EHU ADDI
  • Back
    • English
    • Español
    • Euskera
  • Login
  • English 
    • English
    • Español
    • Euskera
  • FAQ
View Item 
  •   Home
  • INVESTIGACIÓN
  • Grupos de Investigación, Institutos y Centros Colaboradores
  • BCBL
  • BCBL-Publications
  • View Item
  •   Home
  • INVESTIGACIÓN
  • Grupos de Investigación, Institutos y Centros Colaboradores
  • BCBL
  • BCBL-Publications
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Abnormal pattern of brain glucose metabolism in Parkinson’s disease: replication in three European cohorts

Thumbnail
View/Open
Abnormal pattern of brain glucose2020.pdf (1.562Mb)
Date
2020
Author
Meles, Sanne K.
Renken, Remco J.
Pagani, Marco
Teune, L.K.
Arnaldi, Dario
Morbelli, Silvia
Nobili, Flavio
Van Laar, Teus
Obeso, Jose A.
Rodríguez-Oroz, María C.
Leenders, Klaus L.
Metadata
Show full item record
Meles, S.K., Renken, R.J., Pagani, M. et al. Abnormal pattern of brain glucose metabolism in Parkinson’s disease: replication in three European cohorts. Eur J Nucl Med Mol Imaging 47, 437–450 (2020). https://doi.org/10.1007/s00259-019-04570-7
URI
http://hdl.handle.net/10810/42232
Abstract
Rationale In Parkinson’s disease (PD), spatial covariance analysis of 18F-FDG PET data has consistently revealed a characteristic PD-related brain pattern (PDRP). By quantifying PDRP expression on a scan-by-scan basis, this technique allows objective assessment of disease activity in individual subjects. We provide a further validation of the PDRP by applying spatial covariance analysis to PD cohorts from the Netherlands (NL), Italy (IT), and Spain (SP). Methods The PDRPNL was previously identified (17 controls, 19 PD) and its expression was determined in 19 healthy controls and 20 PD patients from the Netherlands. The PDRPIT was identified in 20 controls and 20 “de-novo” PD patients from an Italian cohort. A further 24 controls and 18 “de-novo” Italian patients were used for validation. The PDRPSP was identified in 19 controls and 19 PD patients from a Spanish cohort with late-stage PD. Thirty Spanish PD patients were used for validation. Patterns of the three centers were visually compared and then cross-validated. Furthermore, PDRP expression was determined in 8 patients with multiple system atrophy. Results A PDRP could be identified in each cohort. Each PDRP was characterized by relative hypermetabolism in the thalamus, putamen/pallidum, pons, cerebellum, and motor cortex. These changes co-varied with variable degrees of hypometabolism in posterior parietal, occipital, and frontal cortices. Frontal hypometabolism was less pronounced in “de-novo” PD subjects (Italian cohort). Occipital hypometabolism was more pronounced in late-stage PD subjects (Spanish cohort). PDRPIT, PDRPNL, and PDRPSP were significantly expressed in PD patients compared with controls in validation cohorts from the same center (P < 0.0001), and maintained significance on cross-validation (P < 0.005). PDRP expression was absent in MSA. Conclusion The PDRP is a reproducible disease characteristic across PD populations and scanning platforms globally. Further study is needed to identify the topography of specific PD subtypes, and to identify and correct for center-specific effects.
Collections
  • BCBL-Publications

DSpace software copyright © 2002-2015  DuraSpace
OpenAIRE
OpenAIRE
 

 

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesDepartamentos (cas.)Departamentos (eus.)SubjectsThis CollectionBy Issue DateAuthorsTitlesDepartamentos (cas.)Departamentos (eus.)Subjects

My Account

Login

Statistics

View Usage Statistics

DSpace software copyright © 2002-2015  DuraSpace
OpenAIRE
OpenAIRE