Show simple item record

dc.contributor.authorLizarazu, Mikel
dc.contributor.authorGil Robles, Santiago
dc.contributor.authorPomposo, Iñigo
dc.contributor.authorNara, Sanjeev
dc.contributor.authorAmoruso, Lucia
dc.contributor.authorQuiñones, Ileana
dc.contributor.authorCarreiras, Manuel
dc.date.accessioned2020-03-25T09:21:03Z
dc.date.available2020-03-25T09:21:03Z
dc.date.issued2020
dc.identifier.citationMikel Lizarazu, Santiago Gil-Robles, Iñigo Pomposo, Sanjeev Nara, Lucía Amoruso, Ileana Quiñones, Manuel Carreiras, Spatiotemporal dynamics of postoperative functional plasticity in patients with brain tumors in language areas, Brain and Language, Volume 202, 2020, 104741, ISSN 0093-934X, https://doi.org/10.1016/j.bandl.2019.104741.es_ES
dc.identifier.issn0093-934X
dc.identifier.urihttp://hdl.handle.net/10810/42313
dc.descriptionAvailable online 10 January 2020.es_ES
dc.description.abstractPostoperative functional neuroimaging provides a unique opportunity to investigate the neural mechanisms that facilitate language network reorganization. Previous studies in patients with low grade gliomas (LGGs) in language areas suggest that postoperative recovery is likely due to functional neuroplasticity in peritumoral and contra-tumoral healthy regions, but have attributed varying degrees of importance to specific regions. In this study, we used Magnetoencephalography (MEG) to investigate functional connectivity changes in peritumoral and contra-tumoral regions after brain tumor resection. MEG recordings of cortical activity during resting-state were obtained from 12 patients with LGGs in left-hemisphere language brain areas. MEG data were recorded before (Pre session), and 3 (Post_1 session) and 6 (Post_2 session) months after awake craniotomy. For each MEG session, we measured the functional connectivity of the peritumoral and contra-tumoral regions to the rest of the brain across the 1–100 Hz frequency band. We found that functional connectivity in the Post_1 and Post_2 sessions was higher than in the Pre session only in peritumoral regions and within the alpha frequency band. Functional connectivity in peritumoral regions did not differ between the Post_1 and Post_2 sessions. Alpha connectivity enhancement in peritumoral regions was observed in all patients regardless of the LGG location. Together, these results suggest that postoperative language functional reorganization occurs in peritumoral regions regardless of the location of the tumor and mostly develops within 3 months after surgery.es_ES
dc.description.sponsorshipThe following experiment was performed in accordance to the Ethics of the World Medical Association (Declaration of Helsinki). This research was supported in part by the Basque Government through the BERC 2018-2021 program; the Spanish State Research Agency through BCBL Severo Ochoa excellence accreditation SEV-2015-0490; the ERC- 2011-ADG-295362 from the European Research Council and PSI2015- 67353-R from the MINECO to MC.es_ES
dc.language.isoenges_ES
dc.publisherBrain and Languagees_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/SEV-2015-0490es_ES
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/ERC-2011-ADG-295362es_ES
dc.relationinfo:eu-repo/grantAgreement/MINECO/PSI2015-67353-Res_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.subjectLanguage networkses_ES
dc.subjectLow-grade gliomaes_ES
dc.subjectFunctional reorganizationes_ES
dc.subjectFunctional connectivityes_ES
dc.subjectMagnetoencephalographyes_ES
dc.titleSpatiotemporal dynamics of postoperative functional plasticity in patients with brain tumors in language areases_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.holder© 2020 Elsevier Inc. All rights reserved.es_ES
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/brain-and-languagees_ES
dc.identifier.doi10.1016/j.bandl.2019.104741


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record