dc.contributor.author | Wai Lee, Chuen | |
dc.contributor.author | Blanco, Borja | |
dc.contributor.author | Dempsey, Laura | |
dc.contributor.author | Chalia, Maria | |
dc.contributor.author | Hebden, Jeremy C. | |
dc.contributor.author | Caballero Gaudes, César | |
dc.contributor.author | Austin, Topun | |
dc.contributor.author | Cooper, Robert J. | |
dc.date.accessioned | 2020-04-24T10:02:22Z | |
dc.date.available | 2020-04-24T10:02:22Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Lee CW, Blanco B, Dempsey L, Chalia M, Hebden JC, Caballero-Gaudes C, Austin T and Cooper RJ (2020) Sleep State Modulates Resting-State Functional Connectivity in Neonates. Front. Neurosci. 14:347. doi: 10.3389/fnins.2020.00347 | es_ES |
dc.identifier.issn | 1662-4548 | |
dc.identifier.uri | http://hdl.handle.net/10810/42893 | |
dc.description | Published: 17 April 2020 | es_ES |
dc.description.abstract | The spontaneous cerebral activity that gives rise to resting-state networks (RSNs) has
been extensively studied in infants in recent years. However, the influence of sleep state
on the presence of observable RSNs has yet to be formally investigated in the infant
population, despite evidence that sleep modulates resting-state functional connectivity
in adults. This effect could be extremely important, as most infant neuroimaging
studies rely on the neonate to remain asleep throughout data acquisition. In this
study, we combine functional near-infrared spectroscopy with electroencephalography
to simultaneously monitor sleep state and investigate RSNs in a cohort of healthy term
born neonates. During active sleep (AS) and quiet sleep (QS) our newborn neonates
show functional connectivity patterns spatially consistent with previously reported RSN
structures. Our three independent functional connectivity analyses revealed stronger
interhemispheric connectivity during AS than during QS. In turn, within hemisphere
short-range functional connectivity seems to be enhanced during QS. These findings
underline the importance of sleep state monitoring in the investigation of RSNs. | es_ES |
dc.description.sponsorship | This work was supported by the Medical Research Council (MR/L017490/1), Evelyn Trust (09/26 2013 RTF), EPSRC (EP/N025946/1), and the Basque Government (PRE_2018_2_0154). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers in Neuroscience | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.subject | resting-state functional connectivity | es_ES |
dc.subject | functional near-infrared spectroscopy | es_ES |
dc.subject | sleep state | es_ES |
dc.subject | neonates | es_ES |
dc.subject | connectome | es_ES |
dc.subject | functional imaging | es_ES |
dc.title | Sleep State Modulates Resting-State Functional Connectivity in Neonates | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.holder | Copyright © 2020 Lee, Blanco, Dempsey, Chalia, Hebden, Caballero-Gaudes, Austin and Cooper. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | es_ES |
dc.relation.publisherversion | www.frontiersin.org | es_ES |
dc.identifier.doi | 10.3389/fnins.2020.00347 | |