| dc.contributor.author | Carrión-Castillo, Amaia | |
| dc.contributor.author | Paz-Alonso, Pedro M. | |
| dc.contributor.author | Carreiras, Manuel | |
| dc.date | 10 October 2023 | |
| dc.date.accessioned | 2024-04-12T07:52:20Z | |
| dc.date.available | 2024-04-12T07:52:20Z | |
| dc.date.issued | 2023 | |
| dc.identifier.citation | Carrión-Castillo, A., Paz-Alonso, P.M. & Carreiras, M. Brain structure, phenotypic and genetic correlates of reading performance. Nat Hum Behav 7, 1120–1134 (2023). https://doi.org/10.1038/s41562-023-01583-z | es_ES |
| dc.identifier.citation | Nature Human Behaviour | |
| dc.identifier.issn | 2397-3374 | |
| dc.identifier.uri | http://hdl.handle.net/10810/66627 | |
| dc.description | Published on 10 April 2023 | es_ES |
| dc.description.abstract | Reading is an evolutionarily recent development that recruits and tunes brain circuitry connecting primary- and language-processing regions. We investigated whether metrics of the brain’s physical structure correlate with reading performance and whether genetic variants affect this relationship. To this aim, we used the Adolescent Brain Cognitive Development dataset (n = 9,013) of 9–10-year-olds and focused on 150 measures of cortical surface area (CSA) and thickness. Our results reveal that reading performance is associated with nine measures of brain structure including relevant regions of the reading network. Furthermore, we show that this relationship is partially mediated by genetic factors for two of these measures: the CSA of the entire left hemisphere and, specifically, of the left superior temporal gyrus CSA. These effects emphasize the complex and subtle interplay between genes, brain and reading, which is a partly heritable polygenic skill that relies on a distributed network. | es_ES |
| dc.description.sponsorship | We thank J. Barry and C. Handley for helping with manuscript proofreading. This research is supported by the Basque Government through the BERC 2022–2025 programme and by the Spanish State Research Agency through BCBL Severo Ochoa excellence accreditation no. CEX2020-001010-S. A.C.-C. received funding from the Spanish Ministry of Science and Innovation and the Agencia Estatal de Investigación through Ayudas Juan de la Cierva-Incorporación (ref. no. IJC2018-036023-I), the Programa Fellows Gipuzkoa de atracción y retención de talento from the Diputación Foral de Gipuzkoa. P.M.P-A. is supported by grants from the Spanish Ministry of Science and Innovation (grant no. PID2021-123574NB-I00), from the Basque Government (grant no. PIBA-2021-1-0003) and from the Red guipuzcoana de Ciencia, Tecnología e Innovación of the Diputación Foral de Gipuzkoa (grant no. FA/OF 422/2022). M.C. is supported by the Spanish Ministry of Science and Innovation grant (no. PID2021-122918OB-I00) and ‘La Caixa’ Foundation (grant no. ID 100010434), under the agreement no. HR18-00178-DYSTHAL. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Data used in the preparation of this article were obtained from the ABCD Study (https://abcdstudy.org/) and are held in the National Institute of Mental Health (NIMH) Data Archive. This is a multisite, longitudinal study designed to recruit more than 10,000 children aged 9–10 and follow them over 10 years into early adulthood. The ABCD Study is supported by the NIH and additional federal partners under award numbers U01DA041022, U01DA041028, U01DA041048, U01DA041089, U01DA041106, U01DA041117, U01DA041120, U01DA041134, U01DA041148, U01DA041156, U01DA041174, U24DA041123 and U24DA041147. A full list of supporters is available at https://abcdstudy.org/federal-partners/. A listing of participating sites and a complete listing of the study investigators can be found at https://abcdstudy.org/principal-investigators/. ABCD consortium investigators designed and implemented the study and/or provided data but did not necessarily participate in the analysis or writing of this report. This manuscript reflects the views of the authors and may not reflect the opinions or views of the NIH or ABCD consortium investigators. The ABCD data repository grows and changes over time. The ABCD data used in this report came from https://doi.org/10.15154/1520591 and https://doi.org/10.15154/1519007 (genotyping data). | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | NATURE RESEARCH | es_ES |
| dc.relation | info:eu-repo/grantAgreement/GV/BERC2022-2025 | es_ES |
| dc.relation | info:eu-repo/grantAgreement/AEI/CEX2020-001010-S | es_ES |
| dc.relation | info:eu-repo/grantAgreement/AEI/IJC2018-036023-I | es_ES |
| dc.relation | info:eu-repo/grantAgreement/AEI/PID2021-123574NB-I00 | es_ES |
| dc.relation | info:eu-repo/grantAgreement/GV/PIBA-2021-1-0003 | es_ES |
| dc.relation | info:eu-repo/grantAgreement/DFG/FA/OF422/2022 | es_ES |
| dc.relation | info:eu-repo/grantAgreement/AEI/PID2021-122918OB-I00 | es_ES |
| dc.rights | info:eu-repo/semantics/openAccess | es_ES |
| dc.subject | behavioural genetics | es_ES |
| dc.subject | human behaviour | es_ES |
| dc.subject | reading | es_ES |
| dc.title | Brain structure, phenotypic and genetic correlates of reading performance | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.rights.holder | Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | es_ES |
| dc.relation.publisherversion | https://www.nature.com/nathumbehav/ | es_ES |
| dc.identifier.doi | 10.1038/s41562-023-01583-z | |
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